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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but the involvement of DSB repair in PD-L1 expression has not been investigated. Here we show that PD-L1 expression in ca...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Sato, Hiro, Niimi, Atsuko, Yasuhara, Takaaki, Permata, Tiara Bunga Mayang, Hagiwara, Yoshihiko, Isono, Mayu, Nuryadi, Endang, Sekine, Ryota, Oike, Takahiro, Kakoti, Sangeeta, Yoshimoto, Yuya, Held, Kathryn D., Suzuki, Yoshiyuki, Kono, Koji, Miyagawa, Kiyoshi, Nakano, Takashi, Shibata, Atsushi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701012/
https://ncbi.nlm.nih.gov/pubmed/29170499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01883-9
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