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The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies
The general mechanism involved in Tat activation of RNA Polymerase II (RNAP II) elongation of the integrated HIV-1 was elucidated over 20 years ago. This mechanism involves Tat binding to the TAR RNA element that forms at the 5′ end of viral transcripts and recruiting a general RNAP II elongation fa...
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| Udgivet i: | Curr Pharm Des |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700838/ https://ncbi.nlm.nih.gov/pubmed/28677507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1381612823666170704130635 |
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