Otoferlin acts as a Ca(2+) sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C(2)-domain, Ca(2+)-binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin i...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Michalski, Nicolas, Goutman, Juan D, Auclair, Sarah Marie, Boutet de Monvel, Jacques, Tertrais, Margot, Emptoz, Alice, Parrin, Alexandre, Nouaille, Sylvie, Guillon, Marc, Sachse, Martin, Ciric, Danica, Bahloul, Amel, Hardelin, Jean-Pierre, Sutton, Roger Bryan, Avan, Paul, Krishnakumar, Shyam S, Rothman, James E, Dulon, Didier, Safieddine, Saaid, Petit, Christine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2017
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700815/
https://ncbi.nlm.nih.gov/pubmed/29111973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31013
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