Otoferlin acts as a Ca(2+) sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C(2)-domain, Ca(2+)-binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin i...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Michalski, Nicolas, Goutman, Juan D, Auclair, Sarah Marie, Boutet de Monvel, Jacques, Tertrais, Margot, Emptoz, Alice, Parrin, Alexandre, Nouaille, Sylvie, Guillon, Marc, Sachse, Martin, Ciric, Danica, Bahloul, Amel, Hardelin, Jean-Pierre, Sutton, Roger Bryan, Avan, Paul, Krishnakumar, Shyam S, Rothman, James E, Dulon, Didier, Safieddine, Saaid, Petit, Christine
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700815/
https://ncbi.nlm.nih.gov/pubmed/29111973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31013
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