Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons

Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of LRRK2, linked to the most frequent familial PD, in regulating synaptic vesicle (SV) trafficking. However, the mechanism...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pan, Ping-Yue, Li, Xianting, Wang, Jing, Powell, James, Wang, Qian, Zhang, Yuanxi, Chen, Zhaoyu, Wicinski, Bridget, Hof, Patrick, Ryan, Timothy A., Yue, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700420/
https://ncbi.nlm.nih.gov/pubmed/29054882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0964-17.2017
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