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Radioligand binding analysis of α(2) adrenoceptors with [(11)C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding
We describe a novel method of kinetic analysis of radioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron emission tomography (PET) of [(11)C]yohimbine binding in brain to quantify the density and affinity of α(2) adrenoc...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700124/ https://ncbi.nlm.nih.gov/pubmed/29167492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16020-1 |
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