Radioligand binding analysis of α(2) adrenoceptors with [(11)C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding

We describe a novel method of kinetic analysis of radioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron emission tomography (PET) of [(11)C]yohimbine binding in brain to quantify the density and affinity of α(2) adrenoc...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Phan, Jenny-Ann, Landau, Anne M., Jakobsen, Steen, Wong, Dean F., Gjedde, Albert
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700124/
https://ncbi.nlm.nih.gov/pubmed/29167492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16020-1
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