T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure

We investigated whether CD4(+)-T cells with specificity for an antigen in cardiomyocytes promote the progression from hypertrophy to heart failure in mice with increased pressure load due to transverse aortic constriction (TAC). OT-II mice expressing a transgenic T cell receptor (TCR) with specifici...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gröschel, Carina, Sasse, André, Röhrborn, Charlotte, Monecke, Sebastian, Didié, Michael, Elsner, Leslie, Kruse, Vanessa, Bunt, Gertrude, Lichtman, Andrew H., Toischer, Karl, Zimmermann, Wolfram-Hubertus, Hasenfuß, Gerd, Dressel, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700082/
https://ncbi.nlm.nih.gov/pubmed/29167489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16147-1
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