Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release

Low pH-induced ligand release and receptor recycling are important steps for endocytosis. The transmembrane protein sortilin, a β-propeller containing endocytosis receptor, internalizes a diverse set of ligands with roles in cell differentiation and homeostasis. The molecular mechanisms of pH-mediat...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Leloup, Nadia, Lössl, Philip, Meijer, Dimphna H., Brennich, Martha, Heck, Albert J. R., Thies-Weesie, Dominique M. E., Janssen, Bert J. C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700061/
https://ncbi.nlm.nih.gov/pubmed/29167428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01485-5
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