Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation

OBJECTIVE: Lysine acetylation is an important post-translational modification that regulates metabolic function in skeletal muscle. The acetyltransferase, general control of amino acid synthesis 5 (GCN5), has been proposed as a regulator of mitochondrial biogenesis via its inhibitory action on perox...

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Publicat a:Mol Metab
Autors principals: Dent, Jessica R., Martins, Vitor F., Svensson, Kristoffer, LaBarge, Samuel A., Schlenk, Noah C., Esparza, Mary C., Buckner, Elisa H., Meyer, Gretchen A., Hamilton, D. Lee., Schenk, Simon, Philp, Andrew
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699915/
https://ncbi.nlm.nih.gov/pubmed/29111103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.10.004
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