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Binding kinetics and substrate selectivity in HIV-1 protease−Gag interactions probed at atomic resolution by chemical exchange NMR

The conversion of immature noninfectious HIV-1 particles to infectious virions is dependent upon the sequential cleavage of the precursor group-specific antigen (Gag) polyprotein by HIV-1 protease. The precise mechanism whereby protease recognizes distinct Gag cleavage sites, located in the intrinsi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Deshmukh, Lalit, Tugarinov, Vitali, Louis, John M., Clore, G. Marius
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699096/
https://ncbi.nlm.nih.gov/pubmed/29087351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716098114
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