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Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation

Nucleotidyl cyclases, including membrane-integral and soluble adenylyl and guanylyl cyclases, are central components in a wide range of signaling pathways. These proteins are architecturally diverse, yet many of them share a conserved feature, a helical region that precedes the catalytic cyclase dom...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vercellino, Irene, Rezabkova, Lenka, Olieric, Vincent, Polyhach, Yevhen, Weinert, Tobias, Kammerer, Richard A., Jeschke, Gunnar, Korkhov, Volodymyr M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699072/
https://ncbi.nlm.nih.gov/pubmed/29087332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712621114
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