Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination

Antigen discrimination by T cells occurs at the junction between a T cell and an antigen-presenting cell. Juxtacrine binding between numerous adhesion, signaling, and costimulatory molecules defines both the topographical and lateral geometry of this cell–cell interface, within which T cell receptor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pielak, Rafal M., O’Donoghue, Geoff P., Lin, Jenny J., Alfieri, Katherine N., Fay, Nicole C., Low-Nam, Shalini T., Groves, Jay T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699024/
https://ncbi.nlm.nih.gov/pubmed/29087297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613140114
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