Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism

[Image: see text] Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast cancer risk is largely unknown. In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydro...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Dunlap, Tareisha L., Howell, Caitlin E., Mukand, Nita, Chen, Shao-Nong, Pauli, Guido F., Dietz, Birgit M., Bolton, Judy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698877/
https://ncbi.nlm.nih.gov/pubmed/28985473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00237
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