An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age‐Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Age‐related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease; ho...

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發表在:Stem Cells
Main Authors: Hallam, Dean, Collin, Joseph, Bojic, Sanja, Chichagova, Valeria, Buskin, Adriana, Xu, Yaobo, Lafage, Lucia, Otten, Elsje. G., Anyfantis, George, Mellough, Carla, Przyborski, Stefan, Alharthi, Sameer, Korolchuk, Viktor, Lotery, Andrew, Saretzki, Gabriele, McKibbin, Martin, Armstrong, Lyle, Steel, David, Kavanagh, David, Lako, Majlinda
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
主題:
Translational and Clinical Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698780/
https://ncbi.nlm.nih.gov/pubmed/28913923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2708
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