Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function

Age‐related macular degeneration (AMD) is a multifactorial disease, which is characterized by loss of central vision, affecting one in three people by the age of 75. The Y402H polymorphism in the complement factor H (CFH) gene significantly increases the risk of AMD. We show that Y402H‐AMD‐patient‐s...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Cerniauskas, Edvinas, Kurzawa‐Akanbi, Marzena, Xie, Long, Hallam, Dean, Moya‐Molina, Marina, White, Kathryn, Steel, David, Doherty, Mary, Whitfield, Phil, Al‐Aama, Jumana, Armstrong, Lyle, Kavanagh, David, Lambris, John D., Korolchuk, Viktor I., Harris, Claire, Lako, Majlinda
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695639/
https://ncbi.nlm.nih.gov/pubmed/32815311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0211
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