Radical Hydrodehalogenation of Aryl Bromides and Chlorides with Sodium Hydride and 1,4‐Dioxane

A practical method for radical chain reduction of various aryl bromides and chlorides is introduced. The thermal process uses NaH and 1,4‐dioxane as reagents and 1,10‐phenanthroline as an initiator. Hydrodehalogenation can be combined with typical cyclization reactions, proving the nature of the rad...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Hokamp, Tobias, Dewanji, Abhishek, Lübbesmeyer, Maximilian, Mück‐Lichtenfeld, Christian, Würthwein, Ernst‐Ulrich, Studer, Armido
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698765/
https://ncbi.nlm.nih.gov/pubmed/28841248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706534
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