Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine

We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S‐component of the energy‐coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre‐equilibrated dynamic combinatorial library (DCL) and saturation‐transfer difference (STD) NMR spectroscopy t...

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Publicat a:ChemMedChem
Autors principals: Monjas, Leticia, Swier, Lotteke J. Y. M., Setyawati, Inda, Slotboom, Dirk J., Hirsch, Anna K. H.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698757/
https://ncbi.nlm.nih.gov/pubmed/28960943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700440
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