Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine

We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S‐component of the energy‐coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre‐equilibrated dynamic combinatorial library (DCL) and saturation‐transfer difference (STD) NMR spectroscopy t...

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Detalles Bibliográficos
Publicado en:ChemMedChem
Main Authors: Monjas, Leticia, Swier, Lotteke J. Y. M., Setyawati, Inda, Slotboom, Dirk J., Hirsch, Anna K. H.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698757/
https://ncbi.nlm.nih.gov/pubmed/28960943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700440
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