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Single-molecule visualization of conformational changes and substrate transport in the vitamin B(12) ABC importer BtuCD-F

ATP-binding cassette (ABC) transporters form the largest class of active membrane transport proteins. Binding and hydrolysis of ATP by their highly conserved nucleotide-binding domains drive conformational changes of the complex that mediate transport of substrate across the membrane. The vitamin B(...

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發表在:Nat Commun
Main Authors: Goudsmits, Joris M. H., Slotboom, Dirk Jan, van Oijen, Antoine M.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698293/
https://ncbi.nlm.nih.gov/pubmed/29162829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01815-7
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