Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F

BtuCD-F is an ABC transporter that mediates cobalamin uptake into Escherichia coli. Early in vivo data suggested that BtuCD-F might also be involved in the uptake of cobinamide, a cobalamin precursor. However, neither was it demonstrated that BtuCD-F indeed transports cobinamide, nor was the structu...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mireku, S. A., Ruetz, M., Zhou, T., Korkhov, V. M., Kräutler, B., Locher, K. P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269720/
https://ncbi.nlm.nih.gov/pubmed/28128319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41575
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