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FUNCTIONAL SIGNIFICANCE OF C-TERMINAL MOBILE DOMAIN OF CARDIAC TROPONIN I

Ca(2+)-regulation of cardiac contractility is mediated through the troponin complex, which comprises three subunits: cTnC, cTnI, and cTnT. As intracellular [Ca(2+)] increases, cTnI reduces its binding interactions with actin to primarily interact with cTnC, thereby enabling contraction. A portion of...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Ghashghaee, Nazanin Bohlooli, Tanner, Bertrand C. W., Dong, Wen-Ji
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698173/
https://ncbi.nlm.nih.gov/pubmed/28958680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2017.09.017
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