γδ T cells are required for the induction of sterile immunity during irradiated sporozoite vaccinations

Whole sporozoite vaccines confer sterilizing immunity to malaria-naïve individuals by unknown mechanisms. In the first-ever PfSPZ Vaccine trial in a malaria endemic population, Vδ2 γδT cells were significantly elevated, and Vγ9/Vδ2 transcripts ranked as most-upregulated, in vaccinees that were prote...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Zaidi, Irfan, Diallo, Hama, Conteh, Solomon, Robbins, Yvette, Kolasny, Jacqueline, Orr-Gonzalez, Sachy, Carter, Dariyen, Butler, Brandi, Lambert, Lynn, Brickley, Elizabeth, Morrison, Robert, Sissoko, Mahamadou, Healy, Sara A., Lee Sim, B. Kim, Doumbo, Ogobara K., Hoffman, Stephen L., Duffy, Patrick E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698172/
https://ncbi.nlm.nih.gov/pubmed/29079696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700314
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