Stability of wake-sleep cycles requires robust degradation of the PERIOD protein

Robustness in biology is the stability of phenotype under diverse genetic and/or environmental perturbations. The circadian clock has the remarkable stability of period and phase which—unlike other biological oscillators—is maintained over a wide range of conditions. Here we show that the high fidel...

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Publicado en:Curr Biol
Main Authors: D'Alessandro, Matthew, Beesley, Stephen, Kim, Jae Kyoung, Jones, Zachary, Chen, Rongmin, Wi, Julie, Kyle, Kathleen, Vera, Daniel, Pagano, Michele, Nowakowski, Richard, Lee, Choogon
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698108/
https://ncbi.nlm.nih.gov/pubmed/29103939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.10.014
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