MicroRNA-146a Mimics Reduce the Peripheral Neuropathy in Type 2 Diabetic Mice

MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type 2 diabetes exhibited substantial downregulation of miR-146a in sciatic nerve tissue. Systemic administrat...

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Veröffentlicht in:Diabetes
Hauptverfasser: Liu, Xian Shuang, Fan, Baoyan, Szalad, Alexandra, Jia, Longfei, Wang, Lei, Wang, Xinli, Pan, Wanlong, Zhang, Li, Zhang, Ruilan, Hu, Jiani, Zhang, Xiao Ming, Chopp, Michael, Zhang, Zheng Gang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2017
Schlagworte:
Pharmacology and Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697943/
https://ncbi.nlm.nih.gov/pubmed/28899883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1182
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