Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion

Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive decline in Alzheimer's disease and Down's syndrome. With aging, the partial trisomy 16 (Ts65Dn) mouse model of Down's syndrome exhibited reductions in BFCN size and number and regressive c...

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Detalhes bibliográficos
Main Authors: Cooper, Jonathan D., Salehi, Ahmad, Delcroix, Jean-Dominique, Howe, Charles L., Belichenko, Pavel V., Chua-Couzens, Jane, Kilbridge, Joshua F., Carlson, Elaine J., Epstein, Charles J., Mobley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC56979/
https://ncbi.nlm.nih.gov/pubmed/11504920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181219298
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