Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration

OBJECTIVES: To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity. METHODS: We recruited 48 individuals from families with PSEN1 o...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Weston, Philip S.J., Poole, Teresa, Ryan, Natalie S., Nair, Akshay, Liang, Yuying, Macpherson, Kirsty, Druyeh, Ronald, Malone, Ian B., Ahsan, R. Laila, Pemberton, Hugh, Klimova, Jana, Mead, Simon, Blennow, Kaj, Rossor, Martin N., Schott, Jonathan M., Zetterberg, Henrik, Fox, Nick C.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696646/
https://ncbi.nlm.nih.gov/pubmed/29070659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000004667
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