Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones

The present study aimed to characterize the effects of quinoxaline-derived chalcones, designed on the basis of the selective PI3Kγ inhibitor AS605240, in oral cancer cells. Three lead compounds, namely N9, N17 and N23, were selected from a series of 20 quinoxaline-derived chalcones, based on an init...

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Pubblicato in:Sci Rep
Autori principali: Mielcke, Tânia R., Muradás, Thaís C., Filippi-Chiela, Eduardo C., Amaral, Maria Eduarda A., Kist, Luiza W., Bogo, Maurício R., Mascarello, Alessandra, Neuenfeldt, Patrícia D., Nunes, Ricardo J., Campos, Maria M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696528/
https://ncbi.nlm.nih.gov/pubmed/29158524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16199-3
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