Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain

Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily relieves pain. Here, we explored the possibility that...

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Udgivet i:Sci Rep
Main Authors: Samineni, Vijay K., Mickle, Aaron D., Yoon, Jangyeol, Grajales-Reyes, Jose G., Pullen, Melanie Y., Crawford, Kaitlyn E., Noh, Kyung Nim, Gereau, Graydon B., Vogt, Sherri K., Lai, H. Henry, Rogers, John A., Gereau, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696510/
https://ncbi.nlm.nih.gov/pubmed/29158567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16129-3
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