Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain

Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily relieves pain. Here, we explored the possibility that...

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Foilsithe in:Sci Rep
Main Authors: Samineni, Vijay K., Mickle, Aaron D., Yoon, Jangyeol, Grajales-Reyes, Jose G., Pullen, Melanie Y., Crawford, Kaitlyn E., Noh, Kyung Nim, Gereau, Graydon B., Vogt, Sherri K., Lai, H. Henry, Rogers, John A., Gereau, Robert W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696510/
https://ncbi.nlm.nih.gov/pubmed/29158567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16129-3
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