Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain

Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that severely affects quality of life. Although the underlying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily relieves pain. Here, we explored the possibility that...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Samineni, Vijay K., Mickle, Aaron D., Yoon, Jangyeol, Grajales-Reyes, Jose G., Pullen, Melanie Y., Crawford, Kaitlyn E., Noh, Kyung Nim, Gereau, Graydon B., Vogt, Sherri K., Lai, H. Henry, Rogers, John A., Gereau, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696510/
https://ncbi.nlm.nih.gov/pubmed/29158567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16129-3
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