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Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

Optically active spirocyclic compounds play an important role in drug discovery, and new synthetic strategies for the efficient generation of spiro stereocenters are in much demand. Here we report a catalytic enantioselective cycloaddition using spirocyclic donor–acceptor cyclopropanes as a promisin...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Xu, Peng-Wei, Liu, Jia-Kuan, Shen, Lan, Cao, Zhong-Yan, Zhao, Xiao-Li, Yan, Jun, Zhou, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696380/
https://ncbi.nlm.nih.gov/pubmed/29158496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01451-1
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