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The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
Poly(ADP-ribose) polymerase 1 (PARP1) is involved in DNA repair, chromatin structure, and transcription. However, the mechanisms that regulate PARP1 distribution on DNA are poorly understood. Here, we show that heat shock transcription factor 1 (HSF1) recruits PARP1 through the scaffold protein PARP...
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| Опубликовано в: : | Nat Commun |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5696371/ https://ncbi.nlm.nih.gov/pubmed/29158484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01807-7 |
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