The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis

Poly(ADP-ribose) polymerase 1 (PARP1) is involved in DNA repair, chromatin structure, and transcription. However, the mechanisms that regulate PARP1 distribution on DNA are poorly understood. Here, we show that heat shock transcription factor 1 (HSF1) recruits PARP1 through the scaffold protein PARP...

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Pubblicato in:Nat Commun
Autori principali: Fujimoto, Mitsuaki, Takii, Ryosuke, Takaki, Eiichi, Katiyar, Arpit, Nakato, Ryuichiro, Shirahige, Katsuhiko, Nakai, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696371/
https://ncbi.nlm.nih.gov/pubmed/29158484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01807-7
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