Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype

Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to the brain after aseptic surgical damage. Macrophages are key mediators of innate immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (E...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lee, Jae Hoon, Kam, Eun Hee, Kim, So Yeon, Cheon, So Yeong, Kim, Eun Jung, Chung, Seungsoo, Jeong, Ji-Hyun, Koo, Bon-Nyeo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696349/
https://ncbi.nlm.nih.gov/pubmed/29201007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00839
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