Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype

Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to the brain after aseptic surgical damage. Macrophages are key mediators of innate immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (E...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Lee, Jae Hoon, Kam, Eun Hee, Kim, So Yeon, Cheon, So Yeong, Kim, Eun Jung, Chung, Seungsoo, Jeong, Ji-Hyun, Koo, Bon-Nyeo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696349/
https://ncbi.nlm.nih.gov/pubmed/29201007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00839
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