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Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins

Core fucosylation of N-glycoproteins plays a crucial role in modulating the biological functions of glycoproteins. Yet, the synthesis of structurally well-defined, core-fucosylated glycoproteins remains a challenging task due to the complexity in multi-step chemical synthesis or the inability of the...

詳細記述

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書誌詳細
出版年:J Am Chem Soc
主要な著者: Li, Chao, Zhu, Shilei, Ma, Christopher, Wang, Lai-Xi
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695864/
https://ncbi.nlm.nih.gov/pubmed/28990779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07906
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