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Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins

Core fucosylation of N-glycoproteins plays a crucial role in modulating the biological functions of glycoproteins. Yet, the synthesis of structurally well-defined, core-fucosylated glycoproteins remains a challenging task due to the complexity in multi-step chemical synthesis or the inability of the...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Li, Chao, Zhu, Shilei, Ma, Christopher, Wang, Lai-Xi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695864/
https://ncbi.nlm.nih.gov/pubmed/28990779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07906
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