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Capacity of tTreg generation is not impaired in the atrophied thymus
Postnatal thymic epithelial cell (TEC) homeostatic defect- or natural aging-induced thymic atrophy results in a decline in central T-cell tolerance establishment, which is constituted by thymocyte negative selection and cluster of differentiation (CD) 4(+) thymic regulatory T (tTreg) cell generation...
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| Pubblicato in: | PLoS Biol |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5695848/ https://ncbi.nlm.nih.gov/pubmed/29117183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003352 |
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