Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS

CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (sCD40L) as modifier of glomerular permselectivity d...

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Veröffentlicht in:PLoS One
Hauptverfasser: Doublier, Sophie, Zennaro, Cristina, Musante, Luca, Spatola, Tiziana, Candiano, Giovanni, Bruschi, Maurizio, Besso, Luca, Cedrino, Massimo, Carraro, Michele, Ghiggeri, Gian Marco, Camussi, Giovanni, Lupia, Enrico
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695800/
https://ncbi.nlm.nih.gov/pubmed/29155846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188045
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