YY1 controls Eμ-3′RR DNA loop formation and immunoglobulin heavy chain class switch recombination

Transcription factor YY1 regulates the IgH Eμ-3′RR long-distance DNA loop without the YY1 transcriptional activation domain. YY1 constructs that rescue the Eμ-3′RR DNA loop also restore CSR strongly arguing for the necessity of this long-distance DNA loop for CSR.

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Mehra, Parul, Gerasimova, Tatiana, Basu, Arindam, Jha, Vibha, Banerjee, Anupam, Sindhava, Vishal, Gray, Falon, Berry, Corbett T., Sen, Ranjan, Atchison, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Stimulus Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695717/
https://ncbi.nlm.nih.gov/pubmed/29167838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000372
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