Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life

Activation of CD8(+) cytolytic T lymphocytes (CTLs) by antigen is triggered by the interaction of clonotypic αβ T cell receptors (TCRs) with antigenic peptides bound to MHC class I molecules (pMHC complexes). Fluorescent multimeric pMHC complexes have been shown to specifically stain antigen-specifi...

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Bibliographische Detailangaben
Hauptverfasser: Rubio-Godoy, Verena, Dutoit, Valerie, Rimoldi, Donata, Lienard, Danielle, Lejeune, Ferdy, Speiser, Daniel, Guillaume, Philippe, Cerottini, Jean-Charles, Romero, Pedro, Valmori, Danila
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC56956/
https://ncbi.nlm.nih.gov/pubmed/11517329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181348898
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