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Cancer as the disintegration of robustness: population-level variance in gene expression identifies key differences between tobacco- and HPV-associated oropharyngeal carcinogenesis

CONTEXT: Oropharyngeal squamous cell carcinoma (OPSCC) is associated both with tobacco use and human papillomavirus (HPV) infection. It is argued that carcinogen-driven tumorigenesis is a distinct disease from its virally-driven counterpart. We hypothesized that tumorigenesis is the result of a loss...

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Detalhes bibliográficos
Publicado no:Arch Pathol Lab Med
Main Authors: Ben-Dayan, Miriam M., MacCarthy, Thomas, Schlecht, Nicolas F., Belbin, Thomas J, Childs, Geoffrey, Smith, Richard V., Prystowsky, Michael B., Bergman, Aviv
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695554/
https://ncbi.nlm.nih.gov/pubmed/26132601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5858/arpa.2014-0624-OA
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