Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pa...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Kettner, Nicole M., Voicu, Horatio, Finegold, Milton J, Coarfa, Cristian, Sreekumar, Arun, Putluri, Nagireddy, Katchy, Chinenye A., Lee, Choogon, Moore, David D., Fu, Loning
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695235/
https://ncbi.nlm.nih.gov/pubmed/27889186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.007
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