Inhibition of intimal hyperplasia in murine aortic allografts by administration of a small-molecule TLR4 inhibitor TAK-242

Graft arteriosclerosis (GA) is the leading cause of late cardiac allograft dysfunction. The innate immune system plays a major role in GA, paprticularly Toll-like receptor 4 (TLR4) signaling. Here we characterized the role of TLR4 and its antagonist TAK-242 in a mouse model of GA. BALB/c (H-2d) dono...

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Udgivet i:Sci Rep
Main Authors: Wu, Chuangyan, Ding, Xiangchao, Zhou, Cheng, Ye, Ping, Sun, Yuan, Wu, Jie, Zhang, Anchen, Huang, Xiaofan, Ren, Lingyun, Wang, Ke, Deng, Peng, Yue, Zhang, Chen, Jiuling, Wang, Sihua, Xia, Jiahong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693917/
https://ncbi.nlm.nih.gov/pubmed/29150694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16160-4
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