Proteome-wide map of targets of T790M-EGFR-directed covalent inhibitors

Patients with non-small cell lung cancer (NSCLC) that have kinase-activating epidermal growth factor receptor (EGFR) mutations are highly responsive to first- and second-generation EGFR inhibitors. However, these patients often relapse due to a secondary, drug-resistant mutation in EGFR where the ga...

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Udgivet i:Cell Chem Biol
Main Authors: Niessen, Sherry, Dix, Melissa M., Barbas, Sabrina, Potter, Zachary E., Lu, Shuyan, Brodsky, Oleg, Planken, Simon, Behenna, Douglas, Almaden, Chau, Gajiwala, Ketan S., Ryan, Kevin, Ferre, RoseAnn, Lazear, Michael R, Hayward, Matthew M., Kath, John C., Cravatt, Benjamin F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693604/
https://ncbi.nlm.nih.gov/pubmed/28965727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.017
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