Endothelial cell autophagy maintains shear-stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS

OBJECTIVE: Impaired endothelial cell autophagy compromises shear-stress induced nitric oxide (NO) generation. We determined the responsible mechanism. APPROACH AND RESULTS: Upon autophagy compromise in bovine aortic endothelial cells (ECs) exposed to shear-stress, a decrease in glucose uptake and EC...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Bharath, Leena P, Cho, Jae Min, Park, Seul-Ki, Ruan, Ting, Li, Youyou, Mueller, Robert, Bean, Tyler, Reese, Van, Richardson, Russel S, Cai, Jinjin, Sargsyan, Ashot, Pires, Karla, Babu, Pon Velayutham Anandh, Boudina, Sihem, Graham, Timothy E, Symons, J David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693355/
https://ncbi.nlm.nih.gov/pubmed/28684613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309510
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