Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling

Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling. Genetic ablation of the Cx43 gene (Gja1) results in cortical expansion with accentuated periosteal bone formation associated with decreased express...

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Bibliographic Details
Published in:PLoS One
Main Authors: Grimston, Susan K., Fontana, Francesca, Watkins, Marcus, Civitelli, Roberto
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693294/
https://ncbi.nlm.nih.gov/pubmed/29149200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187980
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