TMIC-42. TOCA 511 AND 5-FC INDUCES T CELL-MEDIATED ANTITUMOR IMMUNITY IN A MOUSE GLIOMA MODEL WHICH IS ENHANCED BY THE ADDITION OF A THERAPEUTIC ANTIBODY AGAINST CTLA-4 AND CORRELATIVE WITH A REDUCTION IN MEMORY T REGULATORY CELLS.

Toca 511 (vocimagene amiretrorepvec) is a gamma retroviral replicating vector that selectively infects cancer cells in vivo and encodes cytosine deaminase. In combination with the prodrug, 5-fluorocytosine (5-FC), Toca 511 produces 5-fluorouracil (5-FU) locally in the tumor microenvironment. This wo...

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Опубликовано в: :Neuro Oncol
Главные авторы: Jolly, Douglas, Mitchell, Leah, Yagiz, Kader, Espinoza, Fernando Lopez, Mendoza, Daniel, Munday, Anthony, Gruber, Harry
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693145/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1030
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