NTOX-09. RECOMMENDED PHASE II DOSE OF INTRA-ARTERIAL MELPHALAN GIVEN WITH INTRA-ARTERIAL CARBOPLATIN, OSMOTIC BLOOD-BRAIN BARRIER DISRUPTION AND DELAYED OTOPROTECTIVE SODIUM THIOSULFATE FOR PATIENTS WITH RECURRENT OR PROGRESSIVE CNS EMBRYONAL OR GERM CELL TUMORS

INTRODUCTION: Intra-arterial chemotherapy in conjunction with transient osmotic BBB disruption (IA/BBBD) has been shown to increase drug delivery (10-100 folds) to the CNS. We report the maximum tolerated dose of IA melphalan in combination with IA carboplatin with BBBD and delayed IV sodium thiosul...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Ambady, Prakash, Doolittle, Nancy, Firkins, Jenny, Netto, Joao Prola, Siler, Dominic, James, Jessica, Johansson, Kirsten, Huddleston, Amy, Fu, Rongwei, Neuwelt, Edward
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Abstracts
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693116/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.676
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