TMOD-28. INTERLEUKIN-13 TARGETED PSEUDOMONAS TOXIN TREATMENT OF MALIGNANT PERIPHERAL NERVE SHEATH TUMORS

Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that arise from peripheral nerves. A target of MPNSTs is the receptor for interleukin-13 (IL-13R). IL-13R has an α1 and α2 subtype, and activation of α1 leads to caspase-3 mediated apoptosis. MPNSTs have increased expression...

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Publicado en:Neuro Oncol
Main Authors: Mrowczynski, Oliver, Payne, Russell, Mau, Christine, Bourcier, Alexandre, Madhankumar, A B, Slagle-Webb, Becky, Harbaugh, Kimberly, Rizk, Elias, Connor, James
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693091/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1065
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