CBIO-05. UNDERSTANDING MECHANISMS OF IDH-MUTANT, 1p19q INTACT GLIOMA PROGRESSION THROUGH USE OF LATEST-GENERATION MASS SPECTROMETRY

Gliomas are the most common primary brain tumors in adults. Driver mutations in Isocitrate Dehydrogenase 1 and 2 (IDH1/2) result in overproduction of an oncometabolite, 2-hydroxy-keto glutartate with subsequent downstream Tp53 mutations or loss of 1p19q. IDH-mutated low grade gliomas have a relative...

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Udgivet i:Neuro Oncol
Main Authors: Cho, Angela, Hayes, Sarah, Hudson, Amanda, Colvin, Emily, Wheeler, Helen, Howell, Viive
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.127
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