EXTH-83. TARGETING DNA REPAIR AND SURVIVAL PATHWAYS THROUGH HEAT SHOCK PROTEIN INHIBITION USING AT13387 TO SENSITIZE GLIOMA TO CHEMORADIATION THERAPY

BACKGROUND: Glioblastoma (GBM) is the most lethal of adult primary brain tumors. Resistance to the standard chemoradiation therapy with temozolomide (TMZ) emerges due to increased expression of DNA-alkylating proteins and potent DNA repair. This is in part through activation of the heat-shock respon...

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Vydáno v:Neuro Oncol
Hlavní autoři: Wu, Jasmine P J, Canella, Alessandro, Xu, Jihong, Lai, Tzung-Huei, Welker, Alessandra M, Beattie, Christine E, Nadella, Vijay, Timmers, Cynthia, Kaur, Balveen, Jacob, Naduparambil, Sampath, Deepa, Puduvalli, Vinay K
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693030/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.373
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