GENE-25. THE HDAC INHIBITOR AR42 ATTENUATES CROSSTALK BETWEEN TWO MUTUALLY-EXCLUSIVE GLIOMA STEM CELL SUBTYPES AND AUGMENTS IMMUNOTHERAPY WITH PD-1 CHECKPOINT BLOCKADE

Accumulating evidence suggests that glioma stem-like cells (GSCs) play crucial roles in therapy resistance and recurrence of glioblastoma (GBM). Previously, we identified two mutually-exclusive GSC subtypes in GBM, termed mesenchymal (MES) and proneural (PN) GSCs, which co-exist in single tumors and...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Yu, Hai, Pavlyukov, Marat, Zhang, Suojun, Bastola, Soniya, Minata, Mutsuko, Alsheikh, Heba Allah, Kang, Kyung-Don, Norian, Lyse, Kagaya, N, Shinya, K, Nakano, Ichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692973/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.399
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